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276526521
Formulation And Evaluation Of In Situ Ocular Gel Of Doxycycline Hyclate
Preces #:
276526521
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- Ocular drug delivery has been a major challenging and interesting field for the pharmaceutical scientists due to unique anatomy and physiology of eye. The major problem encountered in ocular drug delivery is the rapid loss of the drug through lachrymal drainage which results in poor bioavailability and therapeutic response of the drug. The ophthalmic preparations are available as sterile, buffered, isotonic solution. Several types of dosage forms are applied as the delivery system for the ocular delivery of drugs. There are some Prolonged drug delivery can be achieved by various new dosage forms like in-situ gel, collagen shield, minidisc, ocular film, ocusert, nanosuspension, nanoparticulate system, liposomes, niosomes, dendrimers, ocular iontophoresis etc. static(different layers of the eye i.e. cornea, sclera, retina) and dynamic(blood aqueous and blood retinal barrier) barriers which also affect the bioavailability of the drug. The principal advantage of in situ gels is that they can be easily administered with accurate and reproducible dose compared to that of preformed gels and have an advantage that they can be easily instilled in liquid form, In-situ gels are the liquid preparations which upon instillation undergoes phase transition in cul-de-sac of the eye to form a viscous gel and this occurs due to the environmental changes in the eye(i.e. due to change in temperature, change in pH and ion induced change). Carbopol-940 is use as gelling agent in combination with HPMC. This review is to specify the basic anatomy and physiology of human eye, various approaches used for formulation of in-situ gels and polymers used in the formulation of In-situ gels.
| Publisher | Independently published |
| Publication date | 31 Aug. 2023 |
| Edition | Large Print |
| Language | English |
| Print length | 172 pages |
| ISBN-13 | 979-8343918694 |
| Item weight | 281 g |
| Dimensions | 13.97 x 0.99 x 21.59 cm |
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Formulation And Evaluation Of In Situ Ocular Gel Of Doxycycline Hyclate
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